Douroumis Research Group

1. Continuous Manufacturing of High Quality Pharmaceutical Cocrystals Integrated with Process Analytical Tools for In-Line Process Control. H.G. Moradiya, M.T. Islam1, N. Scoutaris, S.A. Halsey, B.Z. Chowdhry, D. Douroumis. Crys. Growth Des. 2016

2. Jet dispensing as a high throughput method for rapid screening and manufacturing of cocrystals N. Scoutaris, A. Anion. A. Hurt, D. Douroumis. CrystEmgCom., 2016

3. Engineering and manufacturing of pharmaceutical co-crystals: A review on solvent-free manufacturing technologies. S. Ross, D. Lamprou, D. Douroumis, Chem. Comm., 2016

4. Development and optimization of ketoconazole oral strips by means of continuous hot-melt extrusion processing. Maniruzzaman M, Farias S, Slipper IJ, Boateng JS, Chowdhry BZ, Nair A, Douroumis D. J Pharm Pharmacol. 2016, doi: 10.1111/jphp

5. Current Trends on Medical and Pharmaceutical Applications of Inkjet Printing Technology. Scoutaris N, Ross S, Douroumis D. Pharm Res. 2016

6. Novel Controlled Release Polymer-Lipid Formulations Processed by Hot Melt Extrusion. Maniruzzaman M, Islam MT, Halsey S, Amin D, Douroumis D. AAPS PharmSciTech. 2016, 17(1):191-9

7. Development and Biological Evaluation of Inkjet Printed Drug Coatings on Intravascular Stent. Scoutaris N, Chai F, Maurel B, Sobocinski J, Zhao M, Moffat JG, Craig DQ, Martel B, Blanchemain N, Douroumis D. Mol Pharm. 2016, 13(1):125-33

8. One-step continuous extrusion process for the manufacturing of solid dispersions. Maniruzzaman M, Nair A, Scoutaris N, Bradley MS, Snowden MJ, Douroumis D. Int J Pharm. 2015, S0378-5173(15)30249-0

9. Continuous twin-screw granulation for enhancing the dissolution of poorly water soluble drug. Maniruzzaman M, Nair A, Renault M, Nandi U, Scoutaris N, Farnish R, Bradley MS, Snowden MJ, Douroumis D. Int J Pharm. 2015, S0378-5173(15)30223-4

10. Inkjet printing of insulin microneedles for transdermal delivery. Ross S, Scoutaris N, Lamprou D, Mallinson D, Douroumis D. Drug Deliv Transl Res. 2015 Aug;5(4):451-61

11. Studies of intermolecular interactions in solid dispersions using advanced surface chemical analysis M. Maniruzzaman, M.J. Snowden,a M.S. Bradley, D. Douroumisa RSC Adv., 2015, 5, 74212-74219

12. Implementation of transmission NIR as a PAT tool for monitoring drug transformation during HME processing. Islam MT, Scoutaris N, Maniruzzaman M, Moradiya HG, Halsey SA, Bradley M, Chowdhry BZ, Snowden MJ, Douroumis D. Eur J Pharm Biopharm. 2015, 106-16

13. Delivery of retinoic acid to LNCap human prostate cancer cells using solid lipid nanoparticles. Akanda MH, Rai R, Slipper IJ, Chowdhry BZ, Lamprou D, Getti G, Douroumis D. Int J Pharm. 2015 30;493(1-2):161-71

14. Bioinspired Titanium Drug Eluting Platforms Based on a Poly-β-cyclodextrin-Chitosan Layer-by-Layer Self-Assembly Targeting Infections. Pérez-Anes A, Gargouri M, Laure W, Van Den Berghe H, Courcot E, Sobocinski J, Tabary N, Chai F, Blach JF, Addad A, Woisel P, Douroumis D, Martel B, Blanchemain N, Lyskawa J. ACS Appl Mater Interfaces. 2015, 7(23):12882-93

15. Taste masked thin films printed by jet dispensing. Scoutaris N, Snowden M, Douroumis D. Int J Pharm. 2015, pii: S0378-5173(15), 428-7

16. A proposal for a drug product Manufacturing Classification System (MCS) for oral solid dosage forms. Leane M, Pitt K, Reynolds G, Douorumis D; Manufacturing Classification System (MCS) Working Group. Pharm Dev Technol. 2015, 20(1):12-21

17. Molecular modelling as a predictive tool for the development of solid dispersions. Maniruzzaman M, Pang, J, Morgan D, Douroumis D. Mol. Pharm. 2015, 12(4):1040-9

18. Inkjet printing of transdermal microneedles for the delivery of anticancer agents. Uddin J, Scoutaris N, Klepetsanis P, Prausnitz M.,Chowdhry B, Douroumis D. Int. J. Pharm. S0378-5173(15), 62-9

19. Increased dissolution rates of carbamazepine – gluconolactone binary blends processed by Hot Melt Extrusion. Moradiya H, Nokhodchi A, Douroumis D. Pharm Dev Technol. 2015, 20, 1-8

20. An in-vitro-in-vivo taste assessment of bitter drug: comparative electronic tongues study. Maniruzzaman M, Douroumis D. J Pharm Pharmacol. 2014, 66(2):323-37

21. SEM/EDX and confocal Raman microscopy as complementary tools for the characterization of pharmaceutical tablets. Scoutaris N, Vithani K, Slipper I, Chowdhry B, Douroumis D. Int J Pharm. 2014, 470(1-2):88-98

22. Development of sustained-release formulations processed by hot-melt extrusion by using a quality-by-design approach. Islam MT, Maniruzzaman M, HalseySA, Chowdhry D. Douroumis. Drug Del. Transl. Res. 2014, 4:377-387

23. Hot Melt Extrusion processing: recent trends. Douroumis D, Europ. Pharm. Rev. 2013 (3):23-27

24. Employing HME as a cost effective method of increasing solubility of water insoluble APIs. Douroumis D, BioPharm Asia, 2014, 50 - 57

25. Continuous cocrystallisation of carbamazepine and trans-cinnamic acid via melt extrusion processing. H.G. Moradiya, M.T. Islam, S. Halsey, M. Maniruzzaman, B.Z. Chowdhry, M.J. Snowden, D. Douroumis CrystEngComm, 2014 014, 16, 3573–358.

26. Continuous Cocrystallization for Dissolution Rate Optimization of a Poorly Water-Soluble Drug. Moradiya H, Islam MT, Woollam G, Slipper IJ, Halsey SA, Snowden MJ, Douroumis D. Cryst. Growth Des., 2014, 14, 189–198

27. Prediction of polymorphic transformations of paracetamol in solid dispersions. Maniruzzaman M, Islam MT, Moradiya HG, Halsey SA, Slipper IJ, Chowdhry BZ, Snowden MJ, Douroumis D. J Pharm Sci. 2014, 103(6):1819-28

28. An in vivo and in vitro Taste Masking Evaluation of Bitter Melt Extruded APIs. M. Maniruzzaman1, M. Bonnefille, A. Aranyos, M.J. Snowden, D. Douroumis. J. Pharm. Pharmacol., 2014, 66(2):323-37

29. Sirolimus Encapsulated Liposomes for Cancer Therapy: Physicochemical and Mechanical Characterization of Sirolimus Distribution within Liposome Bilayers. Onyesom I, Lamprou DA, Sygellou L, Owusu-Ware SK, Antonijevic M, Chowdhry BZ, Douroumis D. Mol Pharm. 2013 10, 4281-93

30. A Review on the Taste Masking of Bitter APIs: Hot-Melt Extrusion (HME) Evaluation. M. Maniruzzaman, B.Z. Chowdhry, M.J. Snowden, D. Douroumis. Drug Dev Ind Pharm 2014, 19, 531-8

31. Study of the Effect of Pressure on Melting Behavior of Saturated Fatty Acids in Liquid or Supercritical Carbon Dioxide V. Trivedi, R. Bhomia, J.C Mitchell, N.J Coleman, D. Douroumis, M.J Snowden. J. Chem. Engi. Data 2013, 58 (6), 1861–1866

32. Sustained release solid lipid matrices processed by hot-melt extrusion (HME). K. Vithani, M. Maniruzzaman, I.J. Slipper, C. Miolane , S. Mostafa, Y. Cuppok, D. Marchaud, D. Douroumis. Colloids Surf B, 2013,10:403-10

33. Diclofenac sodium sustained release hot melt extruded lipid matrices. Pharmaceutical Development and Technology. K. Vithani, Cuppok , S. Mostafa, I.J. Slipper, M. Snowden1, D. Douroumis Pharm Dev Technol. 2014, 19(5):531-8

34. Prostate cancer targeting with 7E11-C5.3 – CdS bioconjugated quantum dots. Sudha Rajaram, Pranav Bhujbal Marco Favretto, Ian Slipper, Dennis Douroumis. J. Colloid Sci. Biotechnol. 2013, 34-39(6)

35. Maniruzzaman M, Morgan DJ, Mendham AP, Pang J, Snowden MJ, Douroumis D. Drug-polymer intermolecular interactions in hot-melt extruded solid dispersions. Int J Pharm. 2013 443(1-2):199-208.

36. Effect of glucosamine HCl on dissolution and solid-state behaviours of piroxicam upon milling. H. Al-Hamidi, A. E. Edwards, D. Douroumis, K.A. Addo, A.R. M. Nayebi, S. Reyhani-Rad, J. Mahmoudi, A. Nokhodchi. Colloids Surf B ., 2013 103:189-99

37. D. Palmer, M. Levina, D. Douroumis, M. Maniruzzaman, D. J. Morgan, T. P. Farrell, A. R. Rajabi-Siahboomi, A. Nokhodchi. The Influence of Synergistic Interactions of Polyethylene Oxide Extended Release Matrix Formulations. Colloids Surf B. 2013 104:174-80

38. M. Maniruzzaman, J. S. Boateng, M.J. Snowden, D. Douroumis. A review of hot-melt extrusion (HME): Process technology to pharmaceutical products. ISRN Pharmaceutics 2012 , 1-9

39. Mesoporous silica nanoparticles in nanotechnolology. D. Douroumis, I. Onyesom, M. Maniruzzaman, J.C Mitchell. Critical Rev. Biotechn. 2013, 33, 229-45

40. Dissolution enhancement of poorly water-soluble APIs processed by hot-melt extrusion (HME) using hydrophilic polymers. D. Douroumis, M. Maniruzzaman, M. Rana, J. Boateng, J.C Mitchell. Drug Dev Ind Pharm 39:218-27

41. Development of poly(glycerol adipate) nanoparticles loaded with non-steroidal anti-inflammatory drugs. A. Wahab, M.E. Favretto, D. Douroumis., M. Casely-Hayford, P. Kallinteri. J. Microenc. 2012;29:497-504

42. Taste Masking of Paracetamol by Hot Melt Extrusion: an in vitro and in vivo evaluation. M. Maniruzzaman, M. Bonnefille, A. Aranyos, J. Boateng, J. Mitchell, D. Douroumis. Eur J. Pharm. Biopharm., 2012, 80(2):433-42

43. Preparation and optimization of PMAA-Chitosan-PEG nanoparticles for oral drug delivery. H. Pawar, J.Boateng, D. Douroumis. Colloids Surf B., 2012, 90:102-8

44. Nano and Microparticle Engineering of Water Insoluble Drugs Using a Novel Spray -Drying Process. N. Schafroth, C. Arpagaus, U.Y. Jadhav, S. Makne. D Douroumis Colloids Surf B., 2012, 90:8-15

45. Inclusion of water insoluble drugs in amorphous silica nanoparticles. A. Patil, A.A Lafarga, M. Chebrot, D. A. Lamprou, A. Urquhart, D. Douroumis.. J. Biomedi. Nanotechn. 2012, 8(4):550-7

46. The Influence of Sodium Carboxymethylcellulose on Drug Release from Polyethylene Oxide Extended Release Matrices. Palmer D, Levina M, Nokhodchi A, Douroumis D, Farrell T, Rajabi-Siahboomi A. AAPS PharmSciTech. 2011, 12(3):862-71

47. Encapsulation of water insoluble drugs in mesoporous silica nanoparticles using supercritical carbon dioxide. A. Patil, U.N. Chirmade, V. Trivedi, D.A. Lamprou, A. Urquhart, D. Douroumis. J. Nanomed & Nanotechn 2011, A211

48. Development and evaluation of orally disintegrating tablets (ODTs) containing Ibuprofen granules prepared by hot melt extrusion. A. Gryczke, S. Schminke, M. Maniruzzaman, J. Beck, D. Douroumis. Colloids Surf B 2011, 86(2):275-84

49. Assessment of fluidity of different invasomes by electron spin resonance and differential scanning calorimetry. Dragicevic-Curic N, Friedrich M, Petersen S, Scheglmann D, Douroumis D, Plass W, Fahr A. Int J Pharm. 412(1-2):85-94

50. In vitro and in silico investigations of drug delivery via zeolite BEA. DG Fatouros, D Douroumis, V Nikolakis, S Ntais, c AM Moschovi, V Trivedi, B Khima, M Roldo, H Nazar, PA. Cox. J. Mater. Chem. 2011, 21, 7789

51. Orally disintegrating dosage forms and taste-masking technologies; 2010. Douroumis D. Expert Opin Drug Deliv. 2011,8(5):665-75.

52. Development and evaluation of Cetirizine HCl taste-masked oral disintegrating tablets. Dennis Douroumis, Andreas Gryczke, Silke Schminke. AAPS PharmSciTech 2010, 12(1):141-51

53. Development of solid lipid nanoparticles for enhanced solubility of poorly soluble drugs. S.G. Potta, S. Minemi, R.K. Nukala, C. Peinado, D.A. Lamprou, A. Urquhart, D. Douroumis. J. Biomed. Nanotech. 2010, 6(6):634-40.

54. Preparation and characterization of Ibuprofen solid lipid nanoparticles with enhanced solubility S.G. Potta, S. Minemi, R.K. Nukala, C. Peinado, D.A. Lamprou, A. Urquhart, D. Douroumis. J. Microencap 2010, 28(1):74-81.

55. A facile synthesis route of size tunable CdS quantum dots with high photoluminescence yield. I.J. Slipper, P. Bhujbal, S. Rajaram, M.E. Favretto, D. Douroumis J. Nanosci. Nanotechn. 2010, 10(9):5899-902

56. Quantum dots (Qds) synthesis and biological applications as imaging and drug delivery systems. O. Obonyo, E. Fisher, M. Edwards, D. Douroumis Critical Rev. Biotech., 2010, 30(4):283-30

57. Controlled release from directly compressible theophylline buccal tablets. H. Boyapally, R.K. Nukala, P. Bhujbal, D. Douroumis. Colloids Surf B, 2010, 77(2):227-33

58. Inclusion of poorly soluble drugs in highly ordered mesoporous silica nanoparticles. M.J.K. Thomas, I. Slipper, A. Walunj, A. Jain, M.E. Favretto, P. Kallinteri, D. Douroumis. Int. J. Pharm. (2010), 387, 272 - 7

59. Application of Electrostatic Dry Powder Deposition Technology for Coating of Drug Eluting Stents. R.K. Nukala, H. Boyapally, I.J. Slipper, A. Menhdam, D. Douroumis. Pharm. Res. (2010) 27 72–81.

60. Chitosan derivatives alter release profiles of model compounds from calcium phosphate implants. S. Green, M. Roldo, D. Douroumis, N. Bouropoulos, D. Lambrou, DG. Fatouros Colloids Surf B, 344 (2009) 901– 7

61. Development of Diltiazem HCl sustained release matrix tablets. H. Boyapally, R.K. Nukala, D. Douroumis. Drug Delivery, 16 (2009) 64–67.

62. Albumin controlled release from alginate-HPMC beads as protein carriers with controlled release properties. A. Nohos, D. Douroumis and N. Bouropoulos. Carbohydrate Polymers, 74, (2008), 451 – 45

63. In Vitro-in Vivo correlation in lipid based formulations using the in vitro dynamic lipolysis model combined with fuzzy neural networks. D.G. Fatouros, F.S. Nielsen, D. Douroumis, L. Hadjileontiadis, A. Müllertz. Eur. J. Pharm. Biopharm., 69, (2008), 887 – 898.

64. Diameter-selective solubilization of carbon nanotubes by lipid micelles. D. Tasis, K. Papagelis, D. Douroumis, Smith, J.R., N. Bouropoulos, D.G. Fatouros. J. Nanosci Nanotech, 8 (2008) 420–423.

65. Using a modified Shepards method for optimization of a nanoparticulate cyclosporine A formulation prepared by a static mixer technique D. Douroumis, S. Scheler, A. Fahr. J. Pharm. Sci, 97 (2008) 19-30

66. Practical approaches of taste masking technologies in oral solid forms (Review). D. Douroumis. Exp Opin Drug Deliv, 4 (2007), 417 – 426.

67. Colloidal stability of carbon nanotubes in an aqueous solution of phospholipids. D. Douroumis, D.G Fatouros, N. Bouropoulos, K. Papagelis, D. Tasis. Int. J. Nanomed, 4 (2007), 761 – 766.

68. Enhanced dissolution of Oxcarbazepine microcrystals using the static mixer process. D. Douroumis and A. Fahr. Coll. Surf. B: Biointerf, 59 (2007) 208 – 214.

69. Physicochemical characterization of solid dispersions of three antiepileptic drugs prepared by solvent evaporation method. Douroumis D, Bouropoulos N, Fahr A. J. Pharm.  Pharmacol., 59, 645 – 653, 2007.

70. Formulation and stabilization of Carbamazepine colloidal suspensions. D. Douroumis, A. Fahr. Eur. J. Pharm. Sci., 30, 367-74, 2007

71. Drug release from differently structured monoolein/ poloxamer nanodispersions studied with differential pulse polarography and ultrafiltration at low pressure. K. Rosenblatt, D. Douroumis, H. Bunjes. J. Pharm. Sci. 96, 1564-1575, 2007.

72. Adaptive Neuro- Fuzzy Modeling of Poorly Soluble Drug Formulations. D. Douroumis, L.J. Hadjileontiadis, and A. Fahr. Pharm. Res., 23, 1157-64, 2006.

73. Nano and micro-particulate formulations of poorly water soluble drugs by using a novel optimized technique. D. Douroumis, Fahr. Eur. J. Pharm. Biopharm, 63 (2):173-5, 2006.

74. Christos G. Kontoyannis, and Dionisis Douroumis. Release Study of Drugs from Liposomic Dispersions using Differential Pulse Polarography. Anal. Chim. Acta 449, 1-2, 135 – 141, 2001.

75. C.G. Kontoyannis, D. Douroumis. A polarographic methodology for continuous non destructive monitoring of drug release from liposomes. Liposomes Research, 2001, 11(1), 255 – 264.

76. C.G. Kontoyannis, D. Douroumis. Determination of liposomes drug retention capacity using differential pulse polarography: the case of chlorothiazide'. Anal. Chim. Acta, 409 (2000) 99-104.

77. CG Kontoyannis, SG Antimisiaris D Douroumis. Simultaneous Quantitative Determination of Drug and Liposomes using Differential Pulse Polarography: the Case of Diazepam. Anal. Chim. Acta, 391, 1999 83-88.

78. C.G. Kontoyannis, S.G. Antimisiaris, D. Douroumis 'Quantitative Determination of Chlorothiazide in the Presence of Liposomes using Differential Pulse Polarography'', Talanta, 48 (1999) 979-983.